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Setdb2 Gene Detail
Summary
  • Symbol
    Setdb2
  • Name
    SET domain, bifurcated 2
  • Synonyms
    KMT1F, LOC239122
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685139
    NCBI Gene: 239122
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr14:59639458-59678329 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 31.48 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    888 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685139
 protein coding gene Chr14:59639458-59678333 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021424
 protein coding gene Chr14:53701202-53741960 (-)
A/J MGP_AJ_G0021383
 protein coding gene Chr14:52576074-52614836 (-)
AKR/J MGP_AKRJ_G0021358
 protein coding gene Chr14:54436525-54474832 (-)
BALB/cJ MGP_BALBcJ_G0021388
 protein coding gene Chr14:52537453-52576294 (-)
C3H/HeJ MGP_C3HHeJ_G0021166
 protein coding gene Chr14:54090406-54133381 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021827
 protein coding gene Chr14:56371076-56413311 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019367
 protein coding gene Chr14:50633290-50672359 (-)
CAST/EiJ MGP_CASTEiJ_G0020682
 protein coding gene Chr14:50497588-50545657 (-)
CBA/J MGP_CBAJ_G0021133
 protein coding gene Chr14:57960970-58006148 (-)
DBA/2J MGP_DBA2J_G0021256
 protein coding gene Chr14:52246278-52284972 (-)
FVB/NJ MGP_FVBNJ_G0021234
 protein coding gene Chr14:51660889-51699716 (-)
LP/J MGP_LPJ_G0021330
 protein coding gene Chr14:54732772-54771467 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021263
 protein coding gene Chr14:57379012-57420629 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021850
 protein coding gene Chr14:53583573-53622521 (-)
PWK/PhJ MGP_PWKPhJ_G0020426
 protein coding gene Chr14:48884320-48923958 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020259
 protein coding gene Chr14:49582592-49630762 (-)
WSB/EiJ MGP_WSBEiJ_G0020735
 protein coding gene Chr14:53897690-53938736 (-)



Homology
more
  • Human Ortholog
    SETDB2, SET domain bifurcated histone lysine methyltransferase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SETDB2, SET domain bifurcated histone lysine methyltransferase 2
  • Synonyms
    C13orf4, CLLD8, CLLL8, KMT1F
  • Links
    NCBI Gene ID: 83852
    neXtProt AC: NX_Q96T68
    UniProt: Q96T68

  • Chr Location
    13q14.2; chr13:49444274-49495003 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic allele exhibit altered response to infection and improved patology following superinfection of influenza virus-infected mice with S. pneumonia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    845
  • Tissues
    110
  • cDNA Data
    28
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 239122 NCBI Gene Model | MGI Sequence Detail 38872 C57BL/6J ±  kb
transcript NM_001320720 RefSeq | MGI Sequence Detail 3000 C57BL/6  
polypeptide Q8C267 UniProt | EBI | MGI Sequence Detail 713 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 30
    cDNA 28
    Primer pair 2

    Microarray probesets 1
References
more
  • Summaries
    All 44
    Developmental Gene Expression 5
    Gene Ontology 10
    Phenotypes 16
  • Earliest
    J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory